实验室丨基础医学院生理与病理生理学系徐国恒课题组
北京大学基础医学院主要从事生物医学领域的基础及应用基础研究，拥有雄厚的科学研究综合实力以及一批具备国际先进水平的科研基地和实验技术平台。本期继续基础医学院生理系实验室推送，一起走进徐国恒课题组！
徐国恒课题组成立于2003年，主要研究方向是脂肪分解及脂肪酸运动，目前实验室成员包括1名老师、7名学生。
一、导师简介
徐国恒教授，博士生导师。1987年毕业于河南医科大学临床医学系，1990年该校药理系硕士毕业，1995年于中山医科大学药理学系获博士学位，入北京医科大学神经科学中心做博士后。1997年底赴美国国立卫生研究院(NIH)儿童健康与人类发育研究所(NICHD) 和糖尿病消化和肾病研究所(NIDDK)做访问研究员。2003年回国于北京大学医学部生理系任教。回国后主要研究脂滴(Lipid Droplet)及脂滴包被蛋白调节，脂肪细胞的脂肪分解的生理病理和药物调节，脂肪代谢异常参与高血压、心肌肥厚发生的病理生理机制，脂肪的筋膜起源研究。承担973项目和国家重大科学研究计划。在J Cell Biol、J Biol Chem、Stem Cells等学术期刊发表SCI研究论文50余篇。
二、实验室研究领域
1、筋膜脂肪形成
2、脂肪分解与代谢
3、脂肪代谢异常相关性疾病
三、实验室团队及培养
1.人员组成
实验室技师：王华旻
博士生：吴碧涵，陈同生，李晗笑，夏莉莎，董迎月
硕士生：张媛媛，孙小喆
实验室地址：北京大学医学部生理楼3层
2.实验室氛围
实验室氛围轻松愉快。
四、实验室代表文章
1.Zhang Y, Su X, Dong Y, Chen T, Zhang Y, Wu B, Li H, Sun X, Xia L, Zhang D, Wang H, and Xu G(*). Cytological and functional characteristics of fascia adipocytes in rats: a unique population of adipocytes. Biochimica et Biophysica Acta–Lipids. 2020;1865(2):158585
2.Zhang D, Dong Y, Zhang Y, Su X, Chen T, Zhang Y, Wu H, and Xu G(*). Spatial distribution and correlation of adipocytes and mast cells in superficial fascia in rats. Histochem Cell Biol. 2019;152(6): 439-451 (IF 2.64)
3.Suning Wei, Shangxin Liu, Xueying Su, Weiyi Wang, Fengjuan Li, Jingna Deng, Ying Lyu, Bin Geng, Guoheng Xu(*). Spontaneous development of hepatosteatosis in perilipin-1 null mice with adipose tissue dysfunction. Biochimica et Biophysica Acta–Molecular and Cell Biology of Lipids. 2018; 1863(2): 212–218 （IF4.966）
4.Juan Tang, Yanfei Zhang, Hao-Yan Yin, Guoheng Xu(*), Jun-Long Zhang(*). Precise Labelling and Tracking Lipid Droplet in Adipocytes Using a Luminescent ZnSalen Complex. Chemistry -An Asian Journal. 2017; 12(19): 2533-2538. (IF 4.083)
5.Xueying Su, Ying Lyu, Weiyi Wang, Yanfei Zhang, Danghua Li, Suning Wei, Congku Du, Bin Geng, Carole Sztalryd, and Guoheng Xu*. Fascia origin of adipose cells. Stem Cells. 2016;34:1407-1419. (IF 5.906)
6.Zou L, Wang W, Liu S, Zhao X, Lyv Y, Du C, Su X, Geng B(*), Xu G(*). Spontaneous hypertension occurs with adipose tissue dysfunction in perilipin-1 null mice. Biochimica et Biophysica Acta –Molecular Basis of Disease. 2016, 1862(2):182-191 (IF 5.476)
7.Wang W, Wei S, Li L, Su X, Du C, Li F, Geng B, Liu P(*), Xu G(*). Proteomic analysis of murine testes lipid droplets. Scientific Reports. 2015; 5: 12070. doi: 10.1038/srep12070. (IF 5.228)
8.Jinhan He(#*), Chong Xu, Jiangying Kuang, Qinhui Liu, Hongfeng Jiang, Li Mo, Bin Geng, and Guoheng Xu(*). Thiazolidinediones attenuate lipolysis and ameliorate dexamethasone-induced insulin resistance. Metabolism - Clinical and Experimental. 2015; 64(7): 826–836. (IF 5.963)
9.Ying Lye, Xueying Su, Jingna Deng, Shangxin Liu, Liangqiang Zou, Xiaojing Zhao, Suning Wei, Bin Geng, and Guoheng Xu(*). Defective differentiation of adipose precursor cells from lipodystrophic mice lacking Perilipin 1. PLoS One. 2015;10(2):e0117536. (IF 3.057)
10.Shangxin Liu, Bin Geng, Liangqiang Zou, Suning Wei, Jingna Deng, Chong Xu, Xiaojing Zhao, Ying Lu, Weiyi Wang, and Guoheng Xu(*). Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction. Cardiovascular Research. 2015, 105(1):20-30. (IF 7.014)
11.Geng B*, Cai B, Liao F, Zheng Y, Zeng Q, Yang J, Cui Q, Tang C, Xu G*. Increase or Decrease Hydrogen Sulfide exert Opposite Lipolysis, but Reduce Global Insulin Resistance in High Fatty Diet Induced Obese Mice. PLoS One. 2013, 8(9): e73892.
12.Deng J, Liu S, Zou L, Xu C, Geng B, and Xu G*. Lipolysis response to endoplasmic reticulum stress in adipose cells. J Biol Chem. 2012, 287(9): 6240-6249
13.Chong Xu, Jinhan He, Hongfeng Jiang, Luxia Zu, Wenjie Zhai, Shenshen Pu, and Guoheng Xu*. Direct effect of glucocorticoids on lipolysis in adipocytes. Molecular Endocrinology, 2009, 23(8): 1161-1170.
14.Luxia Zu, Jinhan He, Hongfeng Jiang, Chong Xu, Shenshen Pu, and Guoheng Xu*. Bacterial Endotoxin Stimulates Adipose Lipolysis via Toll-Like Receptor 4 and Extracellular Signal-Regulated Kinase Pathway. Journal of Biological Chemistry. 2009, 284(9): 5915-26. This article was recommended by F1000 Biology.
15.Luxia Zu, Hongfeng Jiang, Jinhan He, Chong Xu, Shenshen Pu, Meifang Liu, and Guoheng Xu*. Sodium Salicylate Blocks Lipolytic Actions of Tumor Necrosis Factor-a in Rat Adipocytes. Molecular Pharmacology. 2008, 73(1): 215-223
16.Tingting Zhang, Jinhan He, Chong Xu, Luxia Zu, Hongfeng Jiang, Shenshen Pu, Xiaohui Guo, and Guoheng Xu*. Mechanisms of Metformin Inhibiting Lipolytic Response to Isoproterenol in Primary Rat Adipocytes. Journal of Molecular Endocrinology. 2009;42 57-66
17.Hongfeng Jiang, Jinhan He, Shenshen Pu, Chaoshu Tang, and Guoheng Xu*. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Biochimica et Biophysica Acta – Lipid, 2007, 1771(1): 66-74.
18.Tingting Ren, Jinhan He, Hongfeng Jiang, Luxia Zu, Shenshen Pu, Xiaohui Guo*, and Guoheng Xu*. Metformin reduces lipolysis in primary rat adipocytes stimulated by tumor necrosis factor-a or isoproterenol. Journal of Molecular Endocrinology. 2006; 37(1): 175-183.
19.Jinhan He, Hongfeng Jiang, John T. Tansey, Chaoshu Tang, Shenshen Pu, and Guoheng Xu*. Calyculin and Okadaic Acid Promote Perilipin Phosphorylation and Increase Lipolysis in Primary Rat Adipocytes. Biochimica Biophysica Acta -Lipid. 2006; 1761(2): 247-255.
五、联系方式
徐国恒老师邮箱：xug@bjmu.edu.cn
期待大家的加入！
图文：徐国恒
课题组
编辑：高浩萌
审核：索利苹
章琳琪