Cell子刊报道基于突触细胞生物学特征的孤独症社交障碍分型标准
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插图1. mPFC不同类型神经元Rac1活性的双向改变导致社交障碍的示意图。其中，兴奋性谷氨酸能锥体神经元（PN）上Rac1活性上调，通过降低所在神经元兴奋性和谷氨酸递质含量，引起社交障碍，定义为“Rac1上调型”社交障碍；PV阳性抑制性GABA能神经元（PV）上Rac1活性下调，通过增加所在神经元兴奋性和GABA递质含量，引起社交障碍，定义为“Rac1下调型”社交障碍。相比而言，在PN下调Rac1活性或在PV上调Rac1活性，均不影响社交行为。自闭症模型小鼠Shank3B KO呈现出“Rac1上调型”社交障碍的行为表型。通过下调mPFC锥体神经元上Rac1活性或上调神经元兴奋性可有效纠正社交障碍。
论文链接：
https://doi.org/10.1016/j.celrep.2022.111722
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